Web based Drug Database (1.07 Linux)

NITROFURANTOIN

Names
Common Name	NITROFURANTOIN
Other Name	NITROFURANTOIN
Pharmacological Group	NITROFURAN ANTIMICROBIALS
Chemical Name	1-(5-Nitrofurfurylideneamino)hydantoin; 1-(5-Nitrofurfurylideneamino)imidazolidine-2,4-dione
Chemical Group

Attributes

Indications	Contraindications	Prescriber Cautions	Patient Cautions
Toxicity	Side Effects	Liver Disease	Renal Failure
Pregnancy	Lactation	Pharmacological Actions	Diagnostic Procedures
Drugs	Interactions

Indications

Urinary tract infection, site not specified
Urinary tract infection following abortive pregnancy
Paediatric use

Contraindications

Nitrofurantoin allergy
Disorders of porphyrin metabolism
Glucose-6-phosphate dehydrogenase deficiency anaemia
Adverse reaction to nitrofurantoin

Prescriber Cautions

Not for infants under 3
Anaemias should be corrected before treatment with NITROFURANTOIN
Regular liver function tests during prolonged treatment with NITROFURANTOIN
Regular lung function tests during prolonged treatment with NITROFURANTOIN
Electrolyte imbalance should be corrected before treatment with NITROFURANTOIN
CSM/CHM warning regarding hepatotoxicity with NITROFURANTOIN

Patient Cautions

See information on products containing NITROFURANTOIN for specific advice for patients

Toxicity

- None Listed -

Side Effects

Acute hepatitis
Acute pancreatitis
Agranulocytosis
Angioneurotic oedema
Aplastic anaemia
Appetite loss - anorexia
Blood disorders
Chronic active hepatitis
Diarrhoea
Erythema
Gallbladder disorders including Cholestasis
Interstitial pneumonia
Itching
Jaundice
Lung disease
Nausea
Pain in joints - arthralgia
Patches of alopecia
Peripheral neuropathy
Pulmonary fibrosis
Rash
Thrombocytopenia
Vomiting

Liver Disease

NITROFURANTOIN - cholestatic jaundice and hepatitis reported

Renal Failure

Avoid NITROFURANTOIN in mild renal failure
Therapeutic urinary concentrations not achieved
NITROFURANTOIN - risk of peripheral neuropathy in renal failure

Pregnancy

NITROFURANTOIN may produce neonatal haemolysis if used at term
Avoid NITROFURANTOIN in the 3rd TRIMESTER of pregnancy

Lactation

Small amounts of NITROFURANTOIN in breast milk
NITROFURANTOIN - small risk of haemolysis in G6PD deficient infants

Pharmacological Actions

ANTIMICROBIAL effect

Diagnostic Procedures

Serum alkaline phosphatase high
Alanine aminotransferase high

Drugs containing NITROFURANTOIN

NITROFURANTOIN 50mg tablets
NITROFURANTOIN 100mg tablets
FURADANTIN 50mg tablets
FURADANTIN 100mg tablets
MACRODANTIN 50mg capsules
MACRODANTIN 100mg capsules
URANTOIN 50mg tablets
URANTOIN 100mg tablets
MACROBID 100mg m/r capsules
NITROFURANTOIN 100mg m/r caps
NITROFURANT 25mg/5mL s/f susp
NITROFURANTOIN 50mg capsules
NITROFURANTOIN 100mg capsules

Interacting Ingredients

CLOZAPINE
Infrequent reports of NITROFURANTOIN increasing the NEUTROPENIC effect of CLOZAPINE. Potential risk. May need to avoid combination
FOSPHENYTOIN
Infrequent reports of NITROFURANTOIN reducing the SERUM LEVEL of FOSPHENYTOIN. Moderate risk. May need to avoid combination
MAGNESIUM TRISILICATE
Theoretical potential for MAGNESIUM TRISILICATE reducing the GASTRO-INTESTINAL ABSORPTION of NITROFURANTOIN. Moderate risk. May need to avoid combination
METOCLOPRAMIDE HYDROCHLORIDE
Theoretical potential for METOCLOPRAMIDE HYDROCHLORIDE reducing the GASTRO-INTESTINAL ABSORPTION of NITROFURANTOIN. Moderate risk. Increase NITROFURANTOIN dose
NALIDIXIC ACID
Theoretical potential for NITROFURANTOIN reducing the ANTIBACTERIAL effect of NALIDIXIC ACID. Potential risk. Avoid
ORAL CONTRACEPTIVES
Infrequent reports of NITROFURANTOIN reducing the CONTRACEPTIVE EFFECT of ORAL CONTRACEPTIVES. Moderate risk. May need to avoid combination
PHENYTOIN
Infrequent reports of NITROFURANTOIN reducing the SERUM LEVEL of PHENYTOIN. Moderate risk. May need to avoid combination
PHENYTOIN SODIUM
Infrequent reports of NITROFURANTOIN reducing the SERUM LEVEL of PHENYTOIN SODIUM. Moderate risk. May need to avoid combination
PROBENECID
Theoretical potential for PROBENECID increasing the ANTIMICROBIAL effect of NITROFURANTOIN. Moderate risk. Monitor
SULFINPYRAZONE
Theoretical potential for SULFINPYRAZONE increasing the ANTIMICROBIAL effect of NITROFURANTOIN. Moderate risk. Monitor