Web based Drug Database (1.07 Linux)

CARVEDILOL

Names
Common Name	CARVEDILOL
Other Name	CARVEDILOL
Pharmacological Group	BETA BLOCKERS
Chemical Name	1-Carbazol-4-yloxy-3-[2-(2-methoxyphenoxy) ethylamino]propan-2-ol
Chemical Group

Attributes

Indications	Contraindications	Prescriber Cautions	Patient Cautions
Toxicity	Side Effects	Liver Disease	Renal Failure
Pregnancy	Lactation	Pharmacological Actions	Diagnostic Procedures
Drugs	Interactions

Indications

Hypertension
Angina pectoris
Paediatric use
Chronic congestive heart failure

Contraindications

Asthma
Pulse rate - bradycardia
Raynaud's syndrome
Chronic asthmatic bronchitis
Adverse reaction to betablockers
Airways obstruction reversible
Beta blocker contraindicated
Betablocker allergy
Carvedilol contraindicated

Prescriber Cautions

For administration on expert advice only
Withdraw CARVEDILOL gradually over at least a week
Caution in asthma or other obstructive pulmonary disease

Patient Cautions

See information on products containing CARVEDILOL for specific advice for patients

Toxicity

- None Listed -

Side Effects

Dizziness - Very Common
Fatigue/asthenia - Very Common
Headache - Very Common
Abdominal pain - Common
Abnormal weight gain - Common
Asthma - Common
Bradycardia - Common
Diarrhoea - Common
Dry eyes - Common
Dyspnoea - Common
Hyperglycaemia - Common
Hypoglycaemia - Common
Hypotension - Common
Nausea - Common
Oedema - Common
Serum cholesterol raised - Common
Visual symptoms - Common
Vomiting - Common
Cardiac conduction disorders - Uncommon
Chest pain - Uncommon
Cold extremities - Uncommon
Constipation - Uncommon
Exanthema - Uncommon
Heart failure - Uncommon
Impotence - Uncommon
Insomnia - Uncommon
Intermittent claudication - Uncommon
Itching - Uncommon
Lichenified skin - Uncommon
Mood swings - Uncommon
Paraesthesia - Uncommon
Psoriasiform rash - Uncommon
Raynaud's phenomenon - Uncommon
Syncope - Uncommon
Acute renal failure - Rare
Bronchospasm - Rare
Difficulty with micturition - Rare
Dry mouth - Rare
Influenza-like symptoms - Rare
Renal function tests abnormal - Rare
Thrombocytopenia - Rare
ALT/SGPT level abnormal - Very Rare
AST/SGOT level raised - Very Rare
Gamma GT level abnormal - Very Rare
Leucopenia - Very Rare
Atopic dermatitis/eczema
Excessive sweating
Rash

Liver Disease

Avoid CARVEDILOL in liver disease

Renal Failure

Use small starting dose of CARVEDILOL in severe renal failure
CARVEDILOL - may reduce renal blood flow and reduce renal function in severe renal failure
CARVEDILOL - higher serum concentrations after oral administration in severe renal failure

Pregnancy

CARVEDILOL may retard intrauterine fetal growth
CARVEDILOL causes neonatal bradycardia related to maternal dose
Avoid CARVEDILOL in the 1st & 2nd TRIMESTER of pregnancy
Risk of neonatal hypoglycaemia with CARVEDILOL

Lactation

Therapeutic doses of CARVEDILOL unlikely to affect infant
CARVEDILOL unlikely to be excreted in milk
Monitor infant
Possible toxicity from CARVEDILOL due to beta-blocker effect

Pharmacological Actions

BETA ANTAGONIST action effect

Diagnostic Procedures

Urine 5-hydroxyindoleacetic acid high
Total bilirubin high
Creatine kinase low
Serum glucose low

Drugs containing CARVEDILOL

EUCARDIC 12.5 tablets
EUCARDIC 25 tablets
CARVEDILOL 12.5mg tablets
CARVEDILOL 25mg tablets
CARVEDILOL 3.125mg tablets
CARVEDILOL 6.25mg tablets
EUCARDIC 3.125 tablets
EUCARDIC 6.25 tablets
Carvedilol 5mg/5ml susp

Interacting Ingredients

ACETOHEXAMIDE
Infrequent reports of CARVEDILOL increasing the HYPOGLYCAEMIC effect of ACETOHEXAMIDE. Moderate risk. Monitor
ADRENALINE
Likely interaction of CARVEDILOL increasing the HYPERTENSIVE effect of ADRENALINE. Potential risk. Monitor
ADRENALINE [LOCAL]
Likely interaction of CARVEDILOL increasing the HYPERTENSIVE effect of ADRENALINE [LOCAL]. Potential risk. Monitor
ALFUZOSIN HYDROCHLORIDE
Infrequent reports of CARVEDILOL increasing the HYPOTENSIVE effect of ALFUZOSIN HYDROCHLORIDE. Potential risk. May need to avoid combination
ALMOTRIPTAN
Infrequent reports of CARVEDILOL increasing the VASOCONSTRICTOR effect of ALMOTRIPTAN. Potential risk. Avoid
AMINOPHYLLINE
Theoretical potential for CARVEDILOL reducing the BRONCHODILATOR effect of AMINOPHYLLINE. High risk. Avoid
AMIODARONE HYDROCHLORIDE
Likely interaction of CARVEDILOL increasing the ARRHYTHMOGENIC effect of AMIODARONE HYDROCHLORIDE. Potential risk. May need to avoid combination
BAMBUTEROL HYDROCHLORIDE
Infrequent reports of CARVEDILOL reducing the BRONCHODILATOR effect of BAMBUTEROL HYDROCHLORIDE. High risk. Avoid
BECLOMETASONE [INHALED]
Infrequent reports of CARVEDILOL reducing the BRONCHODILATOR effect of BECLOMETASONE [INHALED]. High risk. Avoid
BETAMETHASONE [INHALED]
Infrequent reports of CARVEDILOL reducing the BRONCHODILATOR effect of BETAMETHASONE [INHALED]. High risk. Avoid
BIPHASIC INSULIN ASPART
Infrequent reports of CARVEDILOL increasing the HYPOGLYCAEMIC effect of BIPHASIC INSULIN ASPART. Moderate risk. Monitor
BIPHASIC INSULIN LISPRO
Infrequent reports of CARVEDILOL increasing the HYPOGLYCAEMIC effect of BIPHASIC INSULIN LISPRO. Moderate risk. Monitor
BUDESONIDE [INHALED]
Infrequent reports of CARVEDILOL reducing the BRONCHODILATOR effect of BUDESONIDE [INHALED]. High risk. Avoid
BUFYLLINE
Theoretical potential for CARVEDILOL reducing the BRONCHODILATOR effect of BUFYLLINE. High risk. Avoid
CARBENOXOLONE
Likely interaction of CARBENOXOLONE reducing the HYPOTENSIVE effect of CARVEDILOL. Potential risk. Monitor
CARBENOXOLONE [MOUTH]
Likely interaction of CARBENOXOLONE [MOUTH] reducing the HYPOTENSIVE effect of CARVEDILOL. Potential risk. Monitor
CHLORPROMAZINE
Theoretical potential for CHLORPROMAZINE increasing the HYPOTENSIVE effect of CARVEDILOL. Potential risk. May need to avoid combination
CHLORPROPAMIDE
Infrequent reports of CARVEDILOL increasing the HYPOGLYCAEMIC effect of CHLORPROPAMIDE. Moderate risk. Monitor
CHOLINE THEOPHYLLINATE
Theoretical potential for CARVEDILOL reducing the BRONCHODILATOR effect of CHOLINE THEOPHYLLINATE. High risk. Avoid
CLONIDINE
Likely interaction of CARVEDILOL increasing the HYPOTENSIVE effect of CLONIDINE. Potential risk. May need to avoid combination
CROMOGLICATE [INHALED]
Infrequent reports of CARVEDILOL reducing the BRONCHODILATOR effect of CROMOGLICATE [INHALED]. High risk. Avoid
DARBEPOETIN ALFA
Theoretical potential for DARBEPOETIN ALFA reducing the HYPOTENSIVE effect of CARVEDILOL. Moderate risk. Monitor
DEXIBUPROFEN
Infrequent reports of DEXIBUPROFEN reducing the HYPOTENSIVE effect of CARVEDILOL. Moderate risk. Monitor
DIGITOXIN
Infrequent reports of CARVEDILOL increasing the NEGATIVE CHRONOTROPIC effect of DIGITOXIN. Moderate risk. May need to avoid combination
DIGOXIN
Infrequent reports of CARVEDILOL increasing the NEGATIVE CHRONOTROPIC effect of DIGOXIN. Moderate risk. May need to avoid combination
DIHYDROERGOTAMINE MESILATE
Infrequent reports of DIHYDROERGOTAMINE MESILATE increasing the VASOCONSTRICTOR effect of CARVEDILOL. Moderate risk. Monitor
DILTIAZEM HYDROCHLORIDE
Infrequent reports of DILTIAZEM HYDROCHLORIDE increasing the NEGATIVE INOTROPIC effect of CARVEDILOL. Moderate risk. Monitor
DIPROPHYLLINE
Theoretical potential for CARVEDILOL reducing the BRONCHODILATOR effect of DIPROPHYLLINE. High risk. Avoid
DISOPYRAMIDE
Infrequent reports of CARVEDILOL increasing the NEGATIVE CHRONOTROPIC effect of DISOPYRAMIDE. Moderate risk. May need to avoid combination
DISTIGMINE
Infrequent reports of DISTIGMINE increasing the NEGATIVE CHRONOTROPIC effect of CARVEDILOL. Moderate risk. Monitor
EDROPHONIUM
Infrequent reports of EDROPHONIUM increasing the NEGATIVE CHRONOTROPIC effect of CARVEDILOL. Moderate risk. Monitor
ELETRIPTAN
Infrequent reports of CARVEDILOL increasing the VASOCONSTRICTOR effect of ELETRIPTAN. Potential risk. Avoid
EPHEDRINE HYDROCHLORIDE
Infrequent reports of CARVEDILOL reducing the BRONCHODILATOR effect of EPHEDRINE HYDROCHLORIDE. High risk. Avoid
EPOETIN ALFA
Theoretical potential for EPOETIN ALFA reducing the HYPOTENSIVE effect of CARVEDILOL. Moderate risk. Monitor
EPOETIN BETA
Theoretical potential for EPOETIN BETA reducing the HYPOTENSIVE effect of CARVEDILOL. Moderate risk. Monitor
EPOETIN THETA
Theoretical potential for EPOETIN THETA reducing the HYPOTENSIVE effect of CARVEDILOL. Moderate risk. Monitor
EPOETIN ZETA
Theoretical potential for EPOETIN ZETA reducing the HYPOTENSIVE effect of CARVEDILOL. Moderate risk. Monitor
ERGOTAMINE TARTRATE
Infrequent reports of ERGOTAMINE TARTRATE increasing the VASOCONSTRICTOR effect of CARVEDILOL. Moderate risk. Monitor
FELODIPINE
Infrequent reports of FELODIPINE increasing the NEGATIVE INOTROPIC effect of CARVEDILOL. Moderate risk. Monitor
FENOTEROL HYDROBROMIDE
Infrequent reports of CARVEDILOL reducing the BRONCHODILATOR effect of FENOTEROL HYDROBROMIDE. High risk. Avoid
FLECAINIDE ACETATE
Infrequent reports of CARVEDILOL increasing the BETA ANTAGONIST effect of FLECAINIDE ACETATE. Moderate risk. Monitor
FLUTICASONE [INHALED]
Infrequent reports of CARVEDILOL reducing the BRONCHODILATOR effect of FLUTICASONE [INHALED]. High risk. Avoid
FORMOTEROL
Infrequent reports of CARVEDILOL reducing the BRONCHODILATOR effect of FORMOTEROL. High risk. Avoid
FROVATRIPTAN
Infrequent reports of CARVEDILOL increasing the VASOCONSTRICTOR effect of FROVATRIPTAN. Potential risk. Avoid
GALANTAMINE
Infrequent reports of GALANTAMINE increasing the NEGATIVE CHRONOTROPIC effect of CARVEDILOL. Moderate risk. Monitor
GLIBENCLAMIDE
Infrequent reports of CARVEDILOL increasing the HYPOGLYCAEMIC effect of GLIBENCLAMIDE. Moderate risk. Monitor
GLIBORNURIDE
Infrequent reports of CARVEDILOL increasing the HYPOGLYCAEMIC effect of GLIBORNURIDE. Moderate risk. Monitor
GLICLAZIDE
Infrequent reports of CARVEDILOL increasing the HYPOGLYCAEMIC effect of GLICLAZIDE. Moderate risk. Monitor
GLIMEPIRIDE
Infrequent reports of CARVEDILOL increasing the HYPOGLYCAEMIC effect of GLIMEPIRIDE. Moderate risk. Monitor
GLIPIZIDE
Infrequent reports of CARVEDILOL increasing the HYPOGLYCAEMIC effect of GLIPIZIDE. Moderate risk. Monitor
GLIQUIDONE
Infrequent reports of CARVEDILOL increasing the HYPOGLYCAEMIC effect of GLIQUIDONE. Moderate risk. Monitor
GLYMIDINE
Infrequent reports of CARVEDILOL increasing the HYPOGLYCAEMIC effect of GLYMIDINE. Moderate risk. Monitor
HUMAN INSULIN [INHALED]
Infrequent reports of CARVEDILOL increasing the HYPOGLYCAEMIC effect of HUMAN INSULIN [INHALED]. Moderate risk. Monitor
IBUPROFEN
Infrequent reports of IBUPROFEN reducing the HYPOTENSIVE effect of CARVEDILOL. Moderate risk. Monitor
IBUPROFEN LYSINE
Infrequent reports of IBUPROFEN LYSINE reducing the HYPOTENSIVE effect of CARVEDILOL. Moderate risk. Monitor
INDACATEROL
Infrequent reports of CARVEDILOL reducing the BRONCHODILATOR effect of INDACATEROL. High risk. Avoid
INDOMETACIN
Likely interaction of INDOMETACIN reducing the HYPOTENSIVE effect of CARVEDILOL. Potential risk. Monitor
INDOMETACIN [RECTUM]
Likely interaction of INDOMETACIN [RECTUM] reducing the HYPOTENSIVE effect of CARVEDILOL. Potential risk. Monitor
INSULIN ASPART
Infrequent reports of CARVEDILOL increasing the HYPOGLYCAEMIC effect of INSULIN ASPART. Moderate risk. Monitor
INSULIN DETEMIR
Infrequent reports of CARVEDILOL increasing the HYPOGLYCAEMIC effect of INSULIN DETEMIR. Moderate risk. Monitor
INSULIN GLARGINE
Infrequent reports of CARVEDILOL increasing the HYPOGLYCAEMIC effect of INSULIN GLARGINE. Moderate risk. Monitor
INSULIN GLULISINE
Infrequent reports of CARVEDILOL increasing the HYPOGLYCAEMIC effect of INSULIN GLULISINE. Moderate risk. Monitor
INSULIN LISPRO
Infrequent reports of CARVEDILOL increasing the HYPOGLYCAEMIC effect of INSULIN LISPRO. Moderate risk. Monitor
ISOETARINE HYDROCHLORIDE
Infrequent reports of CARVEDILOL reducing the BRONCHODILATOR effect of ISOETARINE HYDROCHLORIDE. High risk. Avoid
ISOPRENALINE HYDROCHLORIDE
Infrequent reports of CARVEDILOL reducing the BRONCHODILATOR effect of ISOPRENALINE HYDROCHLORIDE. High risk. Avoid
ISOPRENALINE SULPHATE
Infrequent reports of CARVEDILOL reducing the BRONCHODILATOR effect of ISOPRENALINE SULPHATE. High risk. Avoid
ISRADIPINE
Infrequent reports of ISRADIPINE increasing the NEGATIVE INOTROPIC effect of CARVEDILOL. Moderate risk. Monitor
KETOTIFEN
Infrequent reports of CARVEDILOL reducing the BRONCHODILATOR effect of KETOTIFEN. High risk. Avoid
LACIDIPINE
Infrequent reports of LACIDIPINE increasing the NEGATIVE INOTROPIC effect of CARVEDILOL. Moderate risk. Monitor
LERCANIDIPINE
Infrequent reports of LERCANIDIPINE increasing the NEGATIVE INOTROPIC effect of CARVEDILOL. Moderate risk. Monitor
LEVODOPA
Theoretical potential for LEVODOPA increasing the HYPOTENSIVE effect of CARVEDILOL. Moderate risk. May need to avoid combination
LEVOMEPROMAZINE
Theoretical potential for LEVOMEPROMAZINE increasing the HYPOTENSIVE effect of CARVEDILOL. Potential risk. May need to avoid combination
MEFLOQUINE HYDROCHLORIDE
Likely interaction of CARVEDILOL increasing the ARRHYTHMOGENIC effect of MEFLOQUINE HYDROCHLORIDE. Moderate risk. May need to avoid combination
METFORMIN HYDROCHLORIDE
Infrequent reports of CARVEDILOL increasing the HYPOGLYCAEMIC effect of METFORMIN HYDROCHLORIDE. Moderate risk. Monitor
METHOXY POLYETHYLENE GLYCOL EPOETIN BETA
Theoretical potential for METHOXY POLYETHYLENE GLYCOL EPOETIN BETA reducing the HYPOTENSIVE effect of CARVEDILOL. Moderate risk. Monitor
METHYSERGIDE
Infrequent reports of METHYSERGIDE increasing the VASOCONSTRICTOR effect of CARVEDILOL. Moderate risk. Monitor
MONTELUKAST
Infrequent reports of CARVEDILOL reducing the BRONCHODILATOR effect of MONTELUKAST. High risk. Avoid
MOXISYLYTE
Likely interaction of CARVEDILOL increasing the HYPOTENSIVE effect of MOXISYLYTE. Potential risk. May need to avoid combination
MOXONIDINE
Theoretical potential for CARVEDILOL reducing the HYPOTENSIVE effect of MOXONIDINE. Moderate risk. May need to avoid combination
NAPROXEN
Infrequent reports of NAPROXEN reducing the HYPOTENSIVE effect of CARVEDILOL. Moderate risk. Monitor
NAPROXEN SODIUM
Infrequent reports of NAPROXEN SODIUM reducing the HYPOTENSIVE effect of CARVEDILOL. Moderate risk. Monitor
NAPROXEN [RECTUM]
Infrequent reports of NAPROXEN [RECTUM] reducing the HYPOTENSIVE effect of CARVEDILOL. Moderate risk. Monitor
NEDOCROMIL SODIUM
Infrequent reports of CARVEDILOL reducing the BRONCHODILATOR effect of NEDOCROMIL SODIUM. High risk. Avoid
NEOSTIGMINE
Infrequent reports of NEOSTIGMINE increasing the NEGATIVE CHRONOTROPIC effect of CARVEDILOL. Moderate risk. Monitor
NICARDIPINE HYDROCHLORIDE
Infrequent reports of NICARDIPINE HYDROCHLORIDE increasing the NEGATIVE INOTROPIC effect of CARVEDILOL. Moderate risk. Monitor
NIFEDIPINE
Infrequent reports of NIFEDIPINE increasing the NEGATIVE INOTROPIC effect of CARVEDILOL. Moderate risk. Monitor
NIMODIPINE
Infrequent reports of NIMODIPINE increasing the NEGATIVE INOTROPIC effect of CARVEDILOL. Moderate risk. Monitor
NISOLDIPINE
Infrequent reports of NISOLDIPINE increasing the NEGATIVE INOTROPIC effect of CARVEDILOL. Moderate risk. Monitor
ORCIPRENALINE
Infrequent reports of CARVEDILOL reducing the BRONCHODILATOR effect of ORCIPRENALINE. High risk. Avoid
ORCIPRENALINE [INHALED]
Infrequent reports of CARVEDILOL reducing the BRONCHODILATOR effect of ORCIPRENALINE [INHALED]. High risk. Avoid
PIRBUTEROL
Infrequent reports of CARVEDILOL reducing the BRONCHODILATOR effect of PIRBUTEROL. High risk. Avoid
PIROXICAM
Likely interaction of PIROXICAM reducing the HYPOTENSIVE effect of CARVEDILOL. Moderate risk. Monitor
PIROXICAM [RECTUM]
Likely interaction of PIROXICAM [RECTUM] reducing the HYPOTENSIVE effect of CARVEDILOL. Moderate risk. Monitor
PIROXICAM-BETADEX
Likely interaction of PIROXICAM-BETADEX reducing the HYPOTENSIVE effect of CARVEDILOL. Moderate risk. Monitor
PRAZOSIN HYDROCHLORIDE
Infrequent reports of CARVEDILOL increasing the HYPOTENSIVE effect of PRAZOSIN HYDROCHLORIDE. Potential risk. May need to avoid combination
PRENYLAMINE
Likely interaction of CARVEDILOL increasing the NEGATIVE INOTROPIC effect of PRENYLAMINE. High risk. Monitor
PYRIDOSTIGMINE BROMIDE
Infrequent reports of PYRIDOSTIGMINE BROMIDE increasing the NEGATIVE CHRONOTROPIC effect of CARVEDILOL. Moderate risk. Monitor
QUINIDINE
Infrequent reports of CARVEDILOL increasing the NEGATIVE CHRONOTROPIC effect of QUINIDINE. Moderate risk. May need to avoid combination
REPROTEROL HYDROCHLORIDE
Infrequent reports of CARVEDILOL reducing the BRONCHODILATOR effect of REPROTEROL HYDROCHLORIDE. High risk. Avoid
RIFAMPICIN
Likely interaction of RIFAMPICIN reducing the SERUM LEVEL of CARVEDILOL. Moderate risk. Monitor
RIMITEROL HYDROBROMIDE
Infrequent reports of CARVEDILOL reducing the BRONCHODILATOR effect of RIMITEROL HYDROBROMIDE. High risk. Avoid
RITODRINE HYDROCHLORIDE
Infrequent reports of CARVEDILOL reducing the BRONCHODILATOR effect of RITODRINE HYDROCHLORIDE. High risk. Avoid
SALBUTAMOL
Infrequent reports of CARVEDILOL reducing the BRONCHODILATOR effect of SALBUTAMOL. High risk. Avoid
SALBUTAMOL [INHALED]
Infrequent reports of CARVEDILOL reducing the BRONCHODILATOR effect of SALBUTAMOL [INHALED]. High risk. Avoid
SALMETEROL XINAFOATE
Infrequent reports of CARVEDILOL reducing the BRONCHODILATOR effect of SALMETEROL XINAFOATE. High risk. Avoid
SUMATRIPTAN SUCCINATE
Infrequent reports of CARVEDILOL increasing the VASOCONSTRICTOR effect of SUMATRIPTAN SUCCINATE. Potential risk. Avoid
TERAZOSIN HYDROCHLORIDE
Infrequent reports of CARVEDILOL increasing the HYPOTENSIVE effect of TERAZOSIN HYDROCHLORIDE. Potential risk. May need to avoid combination
TERBUTALINE
Infrequent reports of CARVEDILOL reducing the BRONCHODILATOR effect of TERBUTALINE. High risk. Avoid
TERBUTALINE [INHALED]
Infrequent reports of CARVEDILOL reducing the BRONCHODILATOR effect of TERBUTALINE [INHALED]. High risk. Avoid
THEOPHYLLINE
Theoretical potential for CARVEDILOL reducing the BRONCHODILATOR effect of THEOPHYLLINE. High risk. Avoid
TOLAZAMIDE
Infrequent reports of CARVEDILOL increasing the HYPOGLYCAEMIC effect of TOLAZAMIDE. Moderate risk. Monitor
TOLBUTAMIDE
Infrequent reports of CARVEDILOL increasing the HYPOGLYCAEMIC effect of TOLBUTAMIDE. Moderate risk. Monitor
TULOBUTEROL HYDROCHLORIDE
Infrequent reports of CARVEDILOL reducing the BRONCHODILATOR effect of TULOBUTEROL HYDROCHLORIDE. High risk. Avoid
VERAPAMIL HYDROCHLORIDE
Infrequent reports of VERAPAMIL HYDROCHLORIDE increasing the NEGATIVE INOTROPIC effect of CARVEDILOL. Moderate risk. Monitor
ZAFIRLUKAST
Infrequent reports of CARVEDILOL reducing the BRONCHODILATOR effect of ZAFIRLUKAST. High risk. Avoid