Web based Drug Database (1.07 Linux)

CHLORPHENAMINE MALEATE

Names
Common Name	CHLORPHENAMINE MALEATE
Other Name	CHLORPHENIRAMINE MALEATE
Pharmacological Group	H1 ANTAGONIST ANTIHISTAMINES
Chemical Name	(+/-)-3-(4-Chlorophenyl)-NN-dimethyl-3-(2-pyridyl)propylamine hydrogen maleate
Chemical Group

Attributes

Indications	Contraindications	Prescriber Cautions	Patient Cautions
Toxicity	Side Effects	Liver Disease	Renal Failure
Pregnancy	Lactation	Pharmacological Actions	Diagnostic Procedures
Drugs	Interactions

Indications

Hay fever
Drug allergy
Non-drug allergy
Urticaria
Anaphylactic shock
Allergy
Anaphylactic shock due to serum
Urticaria due to serum
Paediatric use

Contraindications

Chlorpheniramine poisoning
Other antihistamine poisoning
Hydroxyzine poisoning
Adverse reaction to antihistamines
Adverse reaction to chlorpheniramine

Prescriber Cautions

Caution in epilepsy
Not for infants under 1
CHLORPHENAMINE MALEATE posesses antimuscarinic activity. Care in glaucoma
Avoid concomitant astemizole or terfenadine (risk of rare, but hazardous, arrhythmias)
CHLORPHENAMINE MALEATE posesses antimuscarinic activity. Care in prostatic enlargement

Patient Cautions

See information on products containing CHLORPHENAMINE MALEATE for specific advice for patients

Toxicity

Nervousness
Irritability
Depression
Hallucinations
Restlessness
Convulsions
Drowsiness
Delirium
Tachycardia
Disorientation
Hyperpyrexia

Side Effects

Abdominal pain
Acute hepatitis
Appetite loss - anorexia
Blurred vision
Cardiac dysrhythmias
Chest pain
Convulsions
Depression
Dizziness
Drowsiness
Drug psychoses
Dry mouth
Dyspepsia
Euphoria
Excessive sweating
Exfoliative dermatitis
Extrapyramidal movements
Fatigue/asthenia
Haemolytic anaemia
Headache
Insomnia
Irritability
Jaundice
Liver function tests abnormal
Locomotor impairment
Myalgia
Nightmares
Palpitations
Paraesthesia
Patches of alopecia
Photosensitiveness
Poor concentration
Rash
Tachycardia
Tinnitus
Tremor
Urinary retention

Liver Disease

Avoid CHLORPHENAMINE MALEATE in liver disease
CHLORPHENAMINE MALEATE may precipitate coma in liver disease

Renal Failure

Consider dose reduction in renal failure to avoid possibility of toxicity, increased sensitivity, and side effects

Pregnancy

No evidence of teratogenicity
Some packs carry warning to avoid CHLORPHENAMINE MALEATE in pregnancy

Lactation

Although CHLORPHENAMINE MALEATE not known to be harmful in breast feeding some manufacturers advise avoid
Significant amounts of some antihistamines in breast milk

Pharmacological Actions

HISTAMINE H1 ANTAGONIST effect
ANTIMUSCARINIC effect
SEDATIVE effect

Diagnostic Procedures

- None Listed -

Drugs containing CHLORPHENAMINE MALEATE

CHLORPHENAMINE 4mg tablets
PIRITON 4mg tablets
PIRITON 2mg/5mL syrup
POLLENASE ANTIHISTAMINE tabs
ALLERIEF 2mg/5mL s/f oral soln
VANTAGE ANTIHISTAMINE 4mg tabs
HAYLEVE 4mg tablets
ALLERCALM 4mg tablets
CHLORPHENAMNE 2mg/5mL s/f soln
CHLORPHENAMINE 2mg/5mL syrup
CHLORPHENAMINE 10mg/1mL inj
TIXYLIX COUGH & COLD linctus
GALPSEUD PLUS linctus
HAYMINE m/r tablets
Anaphylaxis kit - community
Lemsip Flu Strngth Night [OTC]
NUMARK A/HIST TABS 4MG 30
NUMARK A/HIST SYR 150ML
Boots Allergy Rel 4mg tab 30
Lloyd Aller Rel 2mg/5ml 150ml
UNICHEM ALLERG REL SYR 150ML
Boots Allerg Rel Antihist syr
Lloyds All/Rel A/hist 4mg tabs
LEMSIP MAX C/FL DY/NGHT 16
Anaphalaxis kit - hospital
LEMSIP Day & Night capsules 8
Chlorphenamine 50mg/5ml soln
PIRITON allergy tablets 4mg 60
LEMSIP MAX C/FL DY/NGHT 24

Interacting Ingredients

BACLOFEN
Theoretical potential for BACLOFEN increasing the SEDATIVE effect of CHLORPHENAMINE MALEATE. Moderate risk. Monitor
BACLOFEN [INTRATHECAL]
Theoretical potential for BACLOFEN [INTRATHECAL] increasing the SEDATIVE effect of CHLORPHENAMINE MALEATE. Moderate risk. Monitor
BETAHISTINE HYDROCHLORIDE
Theoretical potential for CHLORPHENAMINE MALEATE reducing the HISTAMINE H1 RECEPTOR STIMULANT effect of BETAHISTINE HYDROCHLORIDE. High risk. Avoid
BUPROPION
Likely interaction of CHLORPHENAMINE MALEATE increasing the CONVULSANT effect of BUPROPION. Moderate risk. May need to avoid combination
CLOZAPINE
Likely interaction of CHLORPHENAMINE MALEATE increasing the CNS TOXICITY of CLOZAPINE. Moderate risk. May need to avoid combination
FOSPHENYTOIN
Infrequent reports of CHLORPHENAMINE MALEATE increasing the CNS TOXICITY of FOSPHENYTOIN. Moderate risk. May need to avoid combination
PHENYTOIN
Infrequent reports of CHLORPHENAMINE MALEATE increasing the CNS TOXICITY of PHENYTOIN. Moderate risk. May need to avoid combination
PHENYTOIN SODIUM
Infrequent reports of CHLORPHENAMINE MALEATE increasing the CNS TOXICITY of PHENYTOIN SODIUM. Moderate risk. May need to avoid combination